The African healthcare landscape is at a crossroads. According to the World Health Organization, life expectancy in Africa has increased from an average of 50 years in the early 2000s to approximately 63 years as of 20191. However, the Healthy Life Expectancy (HALE) is lower, around 53 years2. With a 10-year gap between life expectancy and HALE, Africa faces both an urgent need and an opportunity for a healthcare paradigm shift. Non-Communicable Diseases (NCDs) contribute to 46% of all deaths in the region3, and the youth population is expected to touch 880 million by 20504. If these young men and women age in a healthcare system that enables wellness and prevents illness, rather than one that expends resources—time, money, and trained medical talent—to treat illnesses, Africa could develop a healthcare model for the world. This panel aims to discuss the paths and pitfalls towards achieving this vision.